HD Explorer (Release 2.6)
Version 2.6 of the HD Explorer has been released. The following summarizes bug fixes, corrections and enhancements for this release.
HD Explorer Data
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~50 Omics datasets derived from HD and HD-related Omics studies identified within community Omics repositories (e.g. GEO, ArrayExpress, PRIDE, etc.) added to Omics Studies.
- ~1,700 gene sets added to the Gene Set Enrichment Library (HDSigDB). These gene sets were derived through analysis of recently appearing HD and HD-related Omics studies in community Omics databases.
- The set of perturbation gene sets was regenerated in this release, taking advantage of perturbation data curated and added to Perturbation Studies since v2.3 (Nov 2024).
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GeM-GWAS Viewer: Summary statistics of genome-wide association studies to identify genetic modifiers of Huntington’s Disease (HD). Studies include:
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GWAS1-5: Analysis of approximately 9,000 HD individuals with European ancestry, focusing on age at motor onset.
- GWAS1-6: Analysis of approximately 12,000 HD individuals, focusing on identifying modifiers of:
- Blood instability phenotypes
- Clinical phenotypes (DCL3, onset, TFC6)
- Algorithmically predicted quantile phenotypes (bradykinesia, chorea, dystonia, oculomotor, rigidity, SDMT, Stroop word, and TMS)
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Access the HD Explorer:
