HD Application Updates

HD Application Updates

Several existing HDinHD resources have been updated this month, and ties between the underlying data has been strengthened.

  1. The HD Molecular Signature Database (HDSigDB) now contains >1,900 gene sets
    derived from human, mouse, rat, fly and yeast studies. The cumulative data is available
    for download as both Human and Mouse GSEA-compliant GMT libraries, suitable for
    gene set enrichment analysis. A Web browser providing query and filter capabilities has been updated, providing access to rich meta-data curated for each set.
  2. HDinHD now contains information on 32 ‘omics-wide treatment studies within the HD context.
  3. HDinHD’s collection of HD mouse models described at The Jackson LaboratoryMouse Genome Informatics (MGI) and the A Field Guide to Working with  Mouse Models of Huntington’s Disease now contains >100 distinct mouse models.
  4. Meta-data for these HD-centric resources include provenance (via specific links to
    GEO, PRIDE, PubMed, Jackson Labs and MGI) and important experimental data
    curated from the applicable sources. Additionally, through further curation and
    annotation, HDinHD has improved the internal connections from curated mouse
    experiments to the underlying HD mouse models.
Access HD Mouse Models DataAccess HD Treatment Studies DataAccess HDSigHD Data