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Related Articles27 years of prenatal diagnosis for Huntington disease in the United Kingdom. Genet Med. 2018 Dec 14;: Authors: Piña-Aguilar RE, Simpson SA, Alshatti A, Clarke A, Craufurd D, Dorkins H, Doye K, Lahiri N, Lashwood A, Lynch C, Miller C, Morton S, O'Driscoll M, Quarrell OW, Rae D, Strong ... read more

Related ArticlesThe Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials. Molecules. 2018 Dec 11;23(12): Authors: Pohl F, Kong Thoo Lin P Abstract Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present ... read more

Related ArticlesQuantum dots as promising theranostic tools against amyloidosis: A review. Protein Pept Lett. 2018 Dec 11;: Authors: Prabhu MPT, Sarkar N Abstract Amyloids are highly ordered beta sheet rich stable protein aggregates, which have been found to play a significant role in the onset of several degenerative diseases such ... read more

Related ArticlesGM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. Transl Neurodegener. 2018;7:30 Authors: Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D Abstract Background: Amyotrophic lateral sclerosis (ALS) is currently an incurable disease without highly effective pharmacological treatments. The peptide drug GM604 ... read more

Related ArticlesGene Therapy for Neurodegenerative Diseases. Neurotherapeutics. 2018 Dec 12;: Authors: Sudhakar V, Richardson RM Abstract Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through several means, including direct correction of pathogenic mechanisms, neuroprotection, neurorestoration, and symptom control. Therapeutic efficacy is therefore dependent ... read more

Related ArticlesBehind the wheel safety in palliative care: a literature review. BMJ Support Palliat Care. 2018 Dec 06;: Authors: Howard M, Ramsenthaler C Abstract BACKGROUND: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concern among specialist palliative care services about patients ... read more

Related ArticlesPoly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington's Disease Model Mouse. ACS Appl Mater Interfaces. 2017 Jul 19;9(28):24126-24139 Authors: Debnath K, Pradhan N, Singh BK, Jana NR, Jana NR Abstract Prevention and therapeutic strategies for various neurodegenerative diseases focus on inhibiting protein fibrillation, clearing ... read more

Related ArticlesDe-Novo Ligand Design against Mutated Huntington Gene by Ligand-Based Pharmacophore Modeling Approach. Curr Comput Aided Drug Des. 2018 Dec 06;: Authors: Munir A, Malik SI, Malik KA Abstract BACKGROUND: Huntington's disease is characterized by three side effects, including motor disturbances, psychiatric elements, and intellectual weakness. The onset for HD ... read more

TiO2 Nanoparticles Catalyze Oxidation of Huntingtin Exon 1-Derived Peptides Impeding Aggregation: a Quantitative NMR Study of Binding and Kinetics. J Am Chem Soc. 2018 Dec 12;: Authors: Ceccon A, Tugarinov V, Clore GM Abstract Polyglutamine expansion within the N-terminal region of the huntingtin protein results in the formation of intracel-lular ... read more

Related ArticlesChemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance. MBio. 2018 Dec 11;9(6): Authors: Bohlmann L, De Oliveira DMP, El-Deeb IM, Brazel EB, Harbison-Price N, Ong CY, Rivera-Hernandez T, Ferguson SA, Cork AJ, Phan MD, Soderholm AT, Davies MR, Nimmo GR, Dougan G, Schembri MA, Cook GM, McEwan ... read more

Multitarget therapeutic strategies for Alzheimer's disease. Neural Regen Res. 2019 Mar;14(3):437-440 Authors: Ibrahim MM, Gabr MT Abstract Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to ... read more

Related ArticlesA common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers. Nat Commun. 2018 03 15;9(1):1097 Authors: Thibaudeau TA, Anderson RT, Smith DM Abstract Protein accumulation and aggregation with a concomitant loss of proteostasis often contribute to neurodegenerative diseases, and the ubiquitin-proteasome system plays a major role in ... read more

Related ArticlesHigh-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry. J Biol Chem. 2018 Dec 11;: Authors: Son S, Bowie LE, Maiuri T, Hung CLK, Desmond CR, Xia J, Truant R Abstract Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a ... read more

Complexity of the Genetics and Clinical Presentation of Spinocerebellar Ataxia 17. Front Cell Neurosci. 2018;12:429 Authors: Nethisinghe S, Lim WN, Ging H, Zeitlberger A, Abeti R, Pemble S, Sweeney MG, Labrum R, Cervera C, Houlden H, Rosser E, Limousin P, Kennedy A, Lunn MP, Bhatia KP, Wood NW, Hardy J, ... read more

Calcium signalling: A common target in neurological disorders and neurogenesis. Semin Cell Dev Biol. 2018 Dec 05;: Authors: Glaser T, Arnaud Sampaio VF, Lameu C, Ulrich H Abstract Calcium is the ubiquitous second messenger used by any living cell. The fine-tuning of intracellular free calcium [(Ca2+)i] homeostasis and signalling pathways ... read more

Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease. Nitric Oxide. 2018 Dec 05;: Authors: Padovan-Neto FE, Jurkowski L, Murray C, Stutzmann GE, Kwan M, Ghavami A, Beaumont V, Park LC, West AR Abstract In Huntington's disease (HD), corticostriatal and ... read more

Clinical and genetic characteristics of late-onset Huntington's disease. Parkinsonism Relat Disord. 2018 Nov 29;: Authors: Oosterloo M, Bijlsma EK, van Kuijk SM, Minkels F, de Die-Smulders CE, REGISTRY Investigators of the European Huntington's Disease Network, Registry Steering committee, Language coordinators, EHDN's associate site in Singapore Abstract BACKGROUND: The frequency of ... read more

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development. PLoS Comput Biol. 2018 Dec 10;14(12):e1006672 Authors: Zhuravlev AV, Vetrovoy OV, Savvateeva-Popova EV Abstract Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parkinson's disease, senile dementia, etc. The ... read more

Related ArticlesBiomechanistic insights into the roles of oxidative stress in generating complex neurological disorders. Biol Chem. 2018 03 28;399(4):305-319 Authors: Yusuf M, Khan M, Robaian MA, Khan RA Abstract Neurological diseases like Alzheimer's disease, epilepsy, parkinsonism, depression, Huntington's disease and amyotrophic lateral sclerosis prevailing globally are considered to be deeply ... read more

Related ArticlesThrough your eyes or mine? The neural correlates of mental state recognition in Huntington's disease. Hum Brain Mapp. 2018 03;39(3):1354-1366 Authors: Eddy CM, Rickards HE, Hansen PC Abstract Huntington's disease (HD) can impair social cognition. This study investigated whether patients with HD exhibit neural differences to healthy controls ... read more

Related ArticlesHuman Umbilical Cord Matrix Stem Cells Reverse Oxidative Stress-Induced Cell Death and Ameliorate Motor Function and Striatal Atrophy in Rat Model of Huntington Disease. Neurotox Res. 2018 08;34(2):273-284 Authors: Ebrahimi MJ, Aliaghaei A, Boroujeni ME, Khodagholi F, Meftahi G, Abdollahifar MA, Ahmadi H, Danyali S, Daftari M, Sadeghi ... read more

Related ArticlesStimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study. Hum Brain Mapp. 2018 03;39(3):1339-1353 Authors: Papoutsi M, Weiskopf N, Langbehn D, Reilmann R, Rees G, Tabrizi SJ Abstract Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and ... read more

Related ArticlesActivation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease. Exp Neurol. 2018 04;302:112-128 Authors: Fatoba O, Kloster E, Reick C, Saft C, Gold R, Epplen JT, Arning L, Ellrichmann G Abstract Huntington's disease (HD) is a monogenic inherited polyglutamine-mediated ... read more

Related ArticlesGasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol. 2018 03;149:101-109 Authors: Paul BD, Snyder SH Abstract Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike nitric oxide ... read more

Related ArticlesVCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017 02;1863(2):552-559 Authors: Guo X, Qi X Abstract Proteasome-dependent turnover of mitochondrial outer membrane (OMM)-associated proteins is one of the mechanisms for maintaining proper ... read more

Related ArticlesDirect Conversion of Somatic Cells into Induced Neurons. Mol Neurobiol. 2018 01;55(1):642-651 Authors: An N, Xu H, Gao WQ, Yang H Abstract The progressive loss and degeneration of neurons in the central nervous system (CNS), as a result of traumas or diseases including Alzheimer's, Parkinson's, Huntington's disease, stroke, ... read more

Related ArticlesLipid nanoparticles for intranasal administration: application to nose-to-brain delivery. Expert Opin Drug Deliv. 2018 04;15(4):369-378 Authors: Battaglia L, Panciani PP, Muntoni E, Capucchio MT, Biasibetti E, De Bonis P, Mioletti S, Fontanella M, Swaminathan S Abstract INTRODUCTION: The blood brain barrier is a functional barrier allowing the entry into ... read more

Related ArticlesInsights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy. Solid State Nucl Magn Reson. 2017 11;88:1-14 Authors: van der Wel PCA Abstract The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating ... read more

Related ArticlesCorticostriatal network dysfunction in Huntington's disease: Deficits in neural processing, glutamate transport, and ascorbate release. CNS Neurosci Ther. 2018 04;24(4):281-291 Authors: Rebec GV Abstract AIMS: This review summarizes evidence for dysfunctional connectivity between cortical and striatal neurons in Huntington's disease (HD), a fatal neurodegenerative condition caused by a ... read more

Related ArticlesDynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018 01 23;8(1):1405 Authors: Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA Abstract Many neurodegenerative diseases, such as Huntington's disease, are hallmarked by ... read more

Related ArticlesTherapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings. CNS Neurosci Ther. 2018 04;24(4):329-342 Authors: Holley SM, Kamdjou T, Reidling JC, Fury B, Coleal-Bergum D, Bauer G, Thompson LM, Levine MS, Cepeda C Abstract The principal symptoms of Huntington's disease (HD), chorea, ... read more

Related ArticlesInhibition of phosphodiesterases as a strategy to achieve neuroprotection in Huntington's disease. CNS Neurosci Ther. 2018 04;24(4):319-328 Authors: Cardinale A, Fusco FR Abstract Huntington's disease (HD) is a fatal neurodegenerative condition, due to a mutation in the IT15 gene encoding for huntingtin. Currently, disease-modifying therapy is not available ... read more

Related ArticlesNeurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease. CNS Neurosci Ther. 2018 04;24(4):353-363 Authors: Gómez-Pineda VG, Torres-Cruz FM, Vivar-Cortés CI, Hernández-Echeagaray E Abstract AIMS: Neurotrophin-3 (NT-3) is expressed in the mouse striatum; however, it is not clear the NT-3 role in striatal ... read more

Related ArticlesAlteration of GABAergic neurotransmission in Huntington's disease. CNS Neurosci Ther. 2018 04;24(4):292-300 Authors: Garret M, Du Z, Chazalon M, Cho YH, Baufreton J Abstract Hereditary Huntington's disease (HD) is characterized by cell dysfunction and death in the brain, leading to progressive cognitive, psychiatric, and motor impairments. Despite molecular ... read more

Related ArticlesEarly Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools. Sci Rep. 2018 02 02;8(1):2304 Authors: Minnig S, Bragg RM, Tiwana HS, Solem WT, Hovander WS, Vik ES, Hamilton M, Legg SRW, Shuttleworth DD, Coffey SR, Cantle JP, Carroll JB Abstract Apathy is ... read more

Related ArticlesPotassium channel dysfunction in neurons and astrocytes in Huntington's disease. CNS Neurosci Ther. 2018 04;24(4):311-318 Authors: Zhang X, Wan JQ, Tong XP Abstract Huntington's disease (HD) is a late-onset fatal neurodegenerative disease, characterized by progressive movement disorders, psychiatric symptoms, and cognitive impairment. The cytosine-adenine-guanine (CAG) triplet expansion encoding ... read more

Related ArticlesCause or compensation?-Altered neuronal Ca2+ handling in Huntington's disease. CNS Neurosci Ther. 2018 04;24(4):301-310 Authors: Mackay JP, Nassrallah WB, Raymond LA Abstract Huntington's disease (HD) is a hereditary neurodegenerative disorder of typically middle-aged onset for which there is no disease-modifying treatment. Caudate and putamen medium-sized spiny projection neurons ... read more

Related ArticlesInsights into GABAAergic system alteration in Huntington's disease. Open Biol. 2018 Dec 05;8(12): Authors: Hsu YT, Chang YG, Chern Y Abstract Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disease that is characterized by a triad of motor, psychiatric and cognitive impairments. There is still no effective therapy ... read more

Related ArticlesAstrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4. J Cell Biochem. 2018 Dec 05;: Authors: Zhao L, Zhang Q, Liang J, Li J, Tan X, Tang N Abstract BACKGROUND: Astrocyte elevated gene-1 (AEG-1), also known as metadherin, 3D3, and lysine-rich carcinoembryonic antigen-related cell adhesion molecule ... read more

Related ArticlesUpcoming Meetings Related to Huntington's Disease. J Huntingtons Dis. 2018;7(4):403 Authors: PMID: 30507583 [PubMed - in process] ... read more

Related ArticlesA phase IIb, randomised, double-blind, placebo-controlled, dose-ranging investigation of the safety and efficacy of NTCELL® [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease. Parkinsonism Relat Disord. 2018 Nov 13;: Authors: Snow B, Mulroy E, Bok A, Simpson M, Smith A, Taylor K, Lockhart M, ... read more

Related ArticlesTargeting the proteostasis network in Huntington's disease. Ageing Res Rev. 2018 Nov 28;: Authors: Soares TR, Reis SD, Pinho BR, Duchen MR, Oliveira JMA Abstract Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 polyglutamine repeats ... read more

Related ArticlesTreatment of psychiatric disturbances in common hyperkinetic movement disorders. Expert Rev Neurother. 2018 Dec 01;: Authors: Berardelli I, Pasquini M, Conte A, Bologna M, Berardelli A, Fabbrini G Abstract INTRODUCTION: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's ... read more

Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. J Cell Physiol. 2018 Dec 04;: Authors: Qi Z, Huang Z, Xie F, Chen L Abstract Mitochondria play a key role in the maintenance of neuronal function by continuously providing energy. Here, we will ... read more

Medication Management Capacity and Its Neurocognitive Correlates in Huntington's Disease. Arch Clin Neuropsychol. 2018 Dec 05;: Authors: Sumida CA, Van Etten EJ, Lopez FV, Sheppard DP, Pirogovsky-Turk E, Corey-Bloom J, Filoteo JV, Woods SP, Gilbert PE, Schmitter-Edgecombe M Abstract Objective: Although medication management is a necessary daily activity for individuals ... read more

Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules. 2018 Dec 01;23(12): Authors: Szafran BN, Lee JH, Borazjani A, Morrison P, Zimmerman G, Andrzejewski KL, Ross MK, Kaplan BLF Abstract Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS)-induced inflammation in mice, which may serve ... read more

Assessment Scales for Patients with Advanced Huntington's Disease: Comparison of the UHDRS and UHDRS-FAP. Mov Disord Clin Pract. 2018 Sep-Oct;5(5):527-533 Authors: Winder JY, Achterberg WP, Marinus J, Gardiner SL, Roos RAC Abstract Background: The standard clinical assessment tool in Huntington's disease is the Unified Huntington's Disease Rating Scale (UHDRS). In ... read more

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders. Int J Mol Sci. 2018 Nov 30;19(12): Authors: Tarafdar A, Pula G Abstract For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91phox and was considered to be a peculiarity of professional phagocytic ... read more

Novel Approach to Tracking Mutant Huntingtin in Biosamples. Trends Mol Med. 2018 Dec;24(12):978-981 Authors: Trajkovic K, Krainc D Abstract Although the established causative agent in Huntington's disease (HD) is a mutation in a single gene encoding huntingtin protein, the pathogenic cascade preceding neuronal death and disease onset is both incompletely ... read more

Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases. BMC Genomics. 2018 Dec 03;19(1):864 Authors: Oczkowicz M, Szmatoła T, Świątkiewicz M, Pawlina-Tyszko K, Gurgul A, Ząbek T Abstract BACKGROUND: Corn dried ... read more