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Related ArticlesTRiC enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 Aug 17;: Authors: Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C Abstract The cytosolic chaperonin T-complex protein (TCP) 1-ring complex (TRiC) has been shown to exert neuroprotective effects on axonal ... read more

Related ArticlesTolfenamic Acid Attenuates 3-Nitropropionic Acid-Induced Biochemical Alteration in Mice. Neurochem Res. 2018 Aug 17;: Authors: Liu P, Li Y, Liu D, Ji X, Chi T, Li L, Zou L Abstract Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, shows neuroprotective effects and alleviates cognitive deficits in transgenic mouse models of ... read more

Related ArticlesMitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients. Metab Brain Dis. 2018 Aug 17;: Authors: Jędrak P, Mozolewski P, Węgrzyn G, Więckowski MR Abstract Huntington disease (HD) is an autosomal dominant neurodegenerative disorder manifesting as progressive impairment of motor function and different neuropsychiatric ... read more

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018;13(8):e0200626 Authors: Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI Abstract Huntington's Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by deleterious ... read more

Related ArticlesGuarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxid Med Cell Longev. 2018;2018:9241308 Authors: Boasquívis PF, Silva GMM, Paiva FA, Cavalcanti RM, Nunez CV, de Paula Oliveira R Abstract Guarana (Paullinia cupana) is largely consumed ... read more

Compartmentalized devices as tools for investigation of human brain network dynamics. Dev Dyn. 2018 Aug 17;: Authors: Fantuzzo JA, Hart RP, Zahn JD, Pang ZP Abstract Neuropsychiatric disorders have traditionally been difficult to study due to the complexity of the human brain and limited availability of human tissue. Induced pluripotent ... read more

Related ArticlesPlanning for an uncertain future in progressive neurological disease: a qualitative study of patient and family decision-making with a focus on eating and drinking. BMC Neurol. 2018 Aug 16;18(1):115 Authors: Clarke G, Fistein E, Holland A, Tobin J, Barclay S, Barclay S Abstract BACKGROUND: Dysphagia and other eating and ... read more

Related ArticlesPromoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2018 Aug 17;: Authors: Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, ... read more

Related ArticlesFinding the Middle Ground for Autophagic Fusion Requirements. Trends Cell Biol. 2018 Aug 13;: Authors: Corona AK, Jackson WT Abstract Autophagosome/amphisome-lysosome fusion is a highly regulated process at the protein, lipid, and biochemical level. Each primary component of fusion, such as the core SNAREs, HOPS complex, or physical positioning ... read more

Autophagy and Mitochondria: Targets in Neurodegenerative Disorders. CNS Neurol Disord Drug Targets. 2018 Aug 15;: Authors: Kumar A, Dhawan A, Shinde A Abstract Cellular physiology and energy metabolism is maintained by the constant supply of energy furnished by the powerhouses of the cell called mitochondria. Cellular homeostasis depends on the ... read more

New Yes/No Recognition Memory Analysis on the California Verbal Learning Test-3: Clinical Utility in Alzheimer's and Huntington's Disease. J Int Neuropsychol Soc. 2018 Aug 16;:1-9 Authors: Graves LV, Holden HM, Van Etten EJ, Delano-Wood L, Bondi MW, Salmon DP, Corey-Bloom J, Delis DC, Gilbert PE Abstract OBJECTIVES: The third edition ... read more

Related ArticlesThe Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease. Int J Mol Sci. 2018 Aug 14;19(8): Authors: Rosas-Arellano A, Estrada-Mondragón A, Piña R, Mantellero CA, Castro MA Abstract The average life expectancy for humans has increased over the last years. However, the quality of the later stages ... read more

Related Articles[Bioinformatics analysis of genes related to pathogenesis of major depression disorder]. Sheng Li Xue Bao. 2018 Aug 25;70(4):361-368 Authors: Gao LJ, Zhao X, Li JG, Xu Y, Zhang Y Abstract The aim of this study was to screen the genes related to the pathogenesis of major depression disorder (MDD) ... read more

Related ArticlesDeutetrabenazine-Not a Revolution but Welcome Evolution for Treating Chorea in Huntington Disease. JAMA Neurol. 2016 12 01;73(12):1404-1406 Authors: Reilmann R PMID: 27749952 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesREST overexpression in mice causes deficits in spontaneous locomotion. Sci Rep. 2018 Aug 14;8(1):12083 Authors: Lu L, Marisetty A, Liu B, Kamal MM, Gumin J, Veo B, Cai Y, Kassem DH, Weng C, Maynard ME, Hood KN, Fuller GN, Pan ZZ, Cykowski MD, Dash PK, Majumder S Abstract Overexpression ... read more

Related ArticlesPeripheral markers of autophagy in polyglutamine diseases. Neurol Sci. 2018 Jan;39(1):149-152 Authors: Puorro G, Marsili A, Sapone F, Pane C, De Rosa A, Peluso S, De Michele G, Filla A, Saccà F Abstract Polyglutamine disorders are neurodegenerative diseases that share a CAG repeat expansion in the coding region, ... read more

Related ArticlesToward a clinic of temporality? Geriatr Psychol Neuropsychiatr Vieil. 2017 Dec 01;15(4):425-433 Authors: Rivasseau Jonveaux T, Batt M, Trognon A Abstract The discovery of time cells has expanded our knowledge in the field of spatial and temporal information coding and the key role of the hippocampus. The internal clock ... read more

Related ArticlesHow tandem gait stumbled into the neurological exam: a review. Neurol Sci. 2018 Jan;39(1):23-29 Authors: Margolesky J, Singer C Abstract Tandem gait testing is an integral part of the neurological exam. It is informative in a wide variety of disorders ranging from cerebellar disease to vestibular and peripheral ... read more

CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: analysis of lipid raft content. Biochimie. 2018 Aug 11;: Authors: Boussicault L, Kacher R, Lamazière A, Vanhoutte P, Caboche J, Betuing S, Potier MC Abstract Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (mHtt) ... read more

Factors contributing to clinical picture and progression of Huntington's disease. Neural Regen Res. 2018 Aug;13(8):1364-1365 Authors: Zielonka D PMID: 30106046 [PubMed] ... read more

Related ArticlesHuntington's Disease Clinical Trials Corner: August 2018. J Huntingtons Dis. 2018;7(3):279-286 Authors: Rodrigues FB, Wild EJ Abstract In the third edition of the Huntington's Disease Clinical Trials Corner we list all currently registered and ongoing clinical trials, expand on the SIGNAL trial (NCT02481674), and cover the recently finished CREST-E ... read more

Related ArticlesVocalisation as a Viable Assessment for Phenotyping Minipigs Transgenic for the Huntington Gene? J Huntingtons Dis. 2018;7(3):269-278 Authors: Rieke L, Schubert R, Matheis T, Muratori LM, Motlik J, Schramke S, Fels M, Kemper N, Schuldenzucker V, Reilmann R Abstract BACKGROUND: Large animal models, such as the transgenic (tg) Huntington ... read more

Related ArticlesMarriage as Protector for Nursing Home Admission in Huntington's Disease. J Huntingtons Dis. 2018;7(3):251-257 Authors: Winder JY, Achterberg WP, Roos RAC Abstract BACKGROUND: Huntington's disease is a progressive, incurable neurodegenerative disorder and it is not possible to delay onset or progression of the disease. Consequently, the disease leads to ... read more

Related ArticlesHuntington disease: Selective deactivation of Huntington disease mutant allele by CRISPR-Cas9 gene editing. Nat Rev Neurol. 2016 11;12(11):614-615 Authors: Malkki H PMID: 27686048 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesReduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study. J Huntingtons Dis. 2018;7(3):209-222 Authors: McNulty P, Pilcher R, Ramesh R, Necuiniate R, Hughes A, Farewell D, Holmans P, Jones L, REGISTRY Investigators of the European Huntington's Disease Network Abstract BACKGROUND: People with Huntington's disease (HD) have ... read more

Related ArticlesComputational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus. J Huntingtons Dis. 2018;7(3):223-237 Authors: De Souza RAG, Kosior N, Thomson SB, Mathelier A, Zhang AW, Bečanović K, Wasserman WW, Leavitt BR Abstract BACKGROUND: Huntington's disease is a late onset neurological disorder caused by a trinucleotide CAG repeat ... read more

Related ArticlesPET Radioligands for imaging of the PDE10A in human: current status. Neurosci Lett. 2018 Aug 09;: Authors: Boscutti G, A Rabiner E, Plisson C Abstract The development of β+ emitter tracers labelled with carbon-11 or fluorine-18 having optimal characteristics of affinity and selectivity for the phosphodiesterase 10 A protein has ... read more

Related ArticlesLocalization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease. Neurol Sci. 2018 Feb;39(2):275-285 Authors: Cardinale A, Fusco FR, Paldino E, Giampà C, Marino M, Nuzzo MT, D'Angelo V, Laurenti D, Straccia G, Fasano D, Sarnataro D, Squillaro T, Paladino S, Melone MAB Abstract Neuroglobin ... read more

Related ArticlesSuppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Res. 2017 Dec;27(12):1441-1465 Authors: Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, Yao Y, Pan Y, Wen X, Ma L, Hexige S, Ding Y, Luo S, Lu B Abstract ... read more

Related ArticlesHuntington disease: New study challenges the hypothesis of glutamate transporter dysfunction in Huntington disease. Nat Rev Neurol. 2016 05;12(5):251 Authors: Malkki H PMID: 27103473 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesThe Puzzle of Huntington Disease Phenocopies. JAMA Neurol. 2016 09 01;73(9):1056-8 Authors: Dupré N, Rouleau G PMID: 27399805 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesTargeting pericytes for therapeutic approaches to neurological disorders. Acta Neuropathol. 2018 Aug 10;: Authors: Cheng J, Korte N, Nortley R, Sethi H, Tang Y, Attwell D Abstract Many central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match ... read more

Bisphosphonates: Future perspective for neurological disorders. Pharmacol Rep. 2018 Mar 30;70(5):900-907 Authors: Zameer S, Najmi AK, Vohora D, Akhtar M Abstract Neurodegenerative disorders and osteoporosis share some common underlying pathological features including calcium overload, accumulation of toxic chemicals, inflammation and impaired protein prenylation by isoprenoids (farnesyl pyrophosphate and geranylgeranyl pyrophosphate) ... read more

Related ArticlesThe Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer's Disease. J Alzheimers Dis Parkinsonism. 2018;8(3): Authors: Rohn TT, Kim N, Isho NF, Mack JM Abstract Despite a wealth of knowledge gained in the past three decades concerning the molecular underpinnings of Alzheimer's disease (AD), progress towards ... read more

Related ArticlesComplex spatial and temporally defined myelin and axonal degeneration in Huntington disease. Neuroimage Clin. 2018;20:236-242 Authors: Rosas HD, Wilkens P, Salat DH, Mercaldo ND, Vangel M, Yendiki AY, Hersch SM Abstract Although much prior work has focused on the basal ganglia and cortical pathology that defines Huntington's disease (HD), ... read more

Related ArticlesA Classification System to Guide Physical Therapy Management in Huntington Disease: A Case Series. J Neurol Phys Ther. 2017 Jul;41(3):156-163 Authors: Fritz NE, Busse M, Jones K, Khalil H, Quinn L, Members of the Physiotherapy Working Group of the European Huntingtonʼs Disease Network Abstract BACKGROUND AND PURPOSE: Individuals ... read more

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation. Cell Rep. 2018 Aug 07;24(6):1397-1406 Authors: Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J ... read more

Constructing disease onset signatures using multi-dimensional network-structured biomarkers. Biostatistics. 2018 Aug 01;: Authors: Li X, Zeng D, Marder K, Wang Y Abstract Potential disease-modifying therapies for neurodegenerative disorders need to be introduced prior to the symptomatic stage in order to be effective. However, current diagnosis of neurological disorders mostly rely ... read more

Related ArticlesNucleic acid aptamers for neurodegenerative diseases. Biochimie. 2018 Feb;145:73-83 Authors: Bouvier-Müller A, Ducongé F Abstract The increased incidence of neurodegenerative diseases represents a huge challenge for societies. These diseases are characterized by neuronal death and include several different pathologies, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, Huntington's ... read more

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease. J Biol Rhythms. 2018 Aug 07;:748730418790401 Authors: Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS Abstract Huntington's disease (HD) patients suffer from progressive neurodegeneration that results ... read more

Related ArticlesProteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression. Neurosci Bull. 2018 Feb;34(1):74-84 Authors: Guo QH, Tong QH, Lu N, Cao H, Yang L, Zhang YQ Abstract To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) ... read more

Related ArticlesATP Binding Cassette Subfamily A Member 2 (ABCA2) Expression and Methylation are Associated with Alzheimer's Disease. Med Sci Monit. 2017 Dec 10;23:5851-5861 Authors: Hu W, Lin X, Zhang H, Zhao N Abstract BACKGROUND ABCA2 has been genetically linked to Alzheimer's disease (AD) risk, but its mRNA expression and ... read more

Mitochondrial permeability transition pore: a potential drug target for neurodegeneration. Drug Discov Today. 2018 Aug 03;: Authors: Kalani K, Yan SF, Yan SS Abstract The mitochondrial permeability transition pore (mPTP) has been considered a key contributor to cell death, inducing the process in several major neurodegenerative diseases. To date, the ... read more

Related ArticlesCaenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases. Eur J Pharmacol. 2018 Jan 15;819:169-180 Authors: Ma L, Zhao Y, Chen Y, Cheng B, Peng A, Huang K Abstract Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as ... read more

Related ArticlesInhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017 12 26;6: Authors: Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada ... read more

Related ArticlesModulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. Mol Neurobiol. 2017 Oct;54(8):5829-5854 Authors: Reis SD, Pinho BR, Oliveira JMA Abstract Polyglutamine expansion mutations in specific proteins underlie the pathogenesis of a group of progressive neurodegenerative disorders, including Huntington's disease, spinal and bulbar muscular atrophy, dentatorubral-pallidoluysian ... read more

Related ArticlesPredictive testing of minors for Huntington's disease: The UK and Netherlands experiences. Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):35-39 Authors: Quarrell OW, Clarke AJ, Compton C, de Die-Smulders CEM, Fryer A, Jenkins S, Lahiri N, MacLeod R, Miedzybrodzka Z, Morrison PJ, Musgrave H, O'Driscoll M, Strong ... read more

Related ArticlesHuntington's Disease and Mitochondria. Neurotox Res. 2017 Oct;32(3):518-529 Authors: Jodeiri Farshbaf M, Ghaedi K Abstract Huntington's disease (HD) as an inherited neurodegenerative disorder leads to neuronal loss in striatum. Progressive motor dysfunction, cognitive decline, and psychiatric disturbance are the main clinical symptoms of the HD. This disease is ... read more

Related ArticlesStriatal mitochondria response to 3-nitropropionic acid and fish oil treatment. Nutr Neurosci. 2018 Feb;21(2):132-142 Authors: Orozco-Ibarra M, García-Morales J, Calvo-Silva FJ, Fernández-Valverde F, Serrano-García N Abstract BACKGROUND: Mitochondrial dysfunction is involved in neurodegenerative diseases, such as Huntington's disease (HD). 3-Nitropropionic acid (3-NP) is a mitochondrial toxin that specifically ... read more

Related ArticlesPhytochemical treatments target kynurenine pathway induced oxidative stress. Redox Rep. 2018 Dec;23(1):25-28 Authors: Parasram K Abstract OBJECTIVE: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. METHODS: Quinolinic acid, a metabolite of the kynurenine pathway ... read more