NCBI Aggregator

Artif Cells Nanomed Biotechnol. 2026 Dec;54(1):316-331. doi: 10.1080/21691401.2026.2644164. Epub 2026 Apr 24.ABSTRACTAlzheimer's disease (AD) and Huntington's disease (HD) share neuroinflammatory mechanisms, yet their specific immune microenvironments remain poorly understood. Integrating transcriptomic profiles of peripheral blood and frontal cortex tissues with 2,160 immune-related genes, we analysed their shared immunopathology. Differential analysis...Read more

Psychol Health. 2026 May;41(5):674-695. doi: 10.1080/08870446.2025.2474010. Epub 2025 Mar 6.ABSTRACTOBJECTIVE: Irritability has been reported as a common psychological co-occurrence with Huntington's disease (HD). Irritability associated with HD is variously attributed to neurological changes, an understandable response to increasing difficulties with cognition and communication, or a multifactorial combination of the two...Read more

J Neurol. 2026 Apr 21;273(5):285. doi: 10.1007/s00415-026-13825-x.ABSTRACTOBJECTIVE: Apathy is a common and debilitating neuropsychiatric symptom in Huntington's disease (HD), yet its long-term trajectory remains poorly characterized. This study examined changes in apathy in HD gene expansion carriers (HDGECs) over 6 years, using a multidimensional measure, and investigated associations with cognition,...Read more

BMJ Case Rep. 2026 Apr 17;19(4):e269215. doi: 10.1136/bcr-2025-269215.ABSTRACTA woman in her 50s with genetically confirmed Huntington's disease presented with right-sided arm sensory symptoms that evolved over days and persisted for at least 1 month. Neurological examination revealed mild right arm hypoesthesia and mild generalised choreiform movements. Brain MRI demonstrated multiple...Read more

Int J Mol Sci. 2026 Apr 4;27(7):3282. doi: 10.3390/ijms27073282.ABSTRACTNeurodegenerative diseases such as Alzheimer's (AD) and Huntington's (HD) remain major therapeutic challenges due to limited treatment efficacy. Imidazoline I2 receptor (I2-IR) ligands have recently emerged as promising neuroprotective agents, with reported roles in modulating oxidative stress, neuroinflammation, and protein aggregation. This...Read more

J Pharm Pharmacol. 2026 Apr 3;78(4):rgag030. doi: 10.1093/jpp/rgag030.ABSTRACTOBJECTIVES: Huntington's disease (HD) is a neurodegenerative condition characterized by a gradual decline in motor skills, cognitive function, and mental health. The 3-nitropropionic acid (3-NPA) model simulates HD-like pathology, which involves calcium dysregulation. To establish a structural basis for targeting Orai-1, in-silico docking...Read more

PLoS One. 2026 Apr 10;21(4):e0346039. doi: 10.1371/journal.pone.0346039. eCollection 2026.ABSTRACTBACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that causes motor (e.g., chorea) and non-motor symptoms (e.g., neurocognitive, neuropsychiatric and autonomic disturbances). Pain is a frequently reported non-motor symptom in HD, with a prevalence of around 40% in the manifest...Read more

Neurobiol Dis. 2026 Jun 1;223:107381. doi: 10.1016/j.nbd.2026.107381. Epub 2026 Apr 6.ABSTRACTHuntington's Disease (HD) is an autosomal dominant neurodegenerative disorder. Recent clinical research has focused on neurofilament light chain protein (NfL), and cholesterol metabolites as potential fluid biomarkers related to disease progression. Our aim was to explore whether the combined longitudinal...Read more

Biochem Biophys Res Commun. 2026 Jun 4;816:153711. doi: 10.1016/j.bbrc.2026.153711. Epub 2026 Apr 1.ABSTRACTAlthough Huntington's disease - a severe, inherited, neurodegenerative disorder - is primarily caused by a pathological variant of the HTT gene (encoding huntingtin protein) which is characterized by the extension of CAG repeats in the 1st exon exceeding...Read more

J Neurol. 2026 Apr 2;273(4):249. doi: 10.1007/s00415-026-13717-0.ABSTRACTBACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Many studies attempt, besides age and CAG, to understand the factors that impact disease progression. Biological tests measuring several metabolic and inflammatory factors are frequently performed in outpatients, but...Read more

J Neurochem. 2026 Apr;170(4):e70419. doi: 10.1111/jnc.70419.ABSTRACTHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder featuring abnormal cognition, psychiatric symptoms, movement, and gastrointestinal function. It is caused by a tandem-repeat gene mutation encoding an expanded polyglutamine tract in the huntingtin protein. Our group was the first to demonstrate gut microbial disruption...Read more

Sci Adv. 2026 Mar 27;12(13):eaeb1174. doi: 10.1126/sciadv.aeb1174. Epub 2026 Mar 27.ABSTRACTMitochondrial dysfunction and dysregulated proteolysis drive Huntington's disease (HD), tauopathy, and related neurodegenerative disorders. Calpain-2, a Ca2+-activated protease restrained by calpastatin (CAST), is pathologically overactivated, yet no therapies directly target this axis. We identify A36, a brain-penetrant small molecule derived...Read more

Turk Psikiyatri Derg. 2026;37:49-53. doi: 10.5080/u27742.ABSTRACTHuntington’s disease (HD) is an autosomal dominant neurodegenerative disease. Its clinical presentation is primarily characterized by motor dysfunction, cognitive decline, and a broad spectrum of neuropsychiatric symptoms. Common psychiatric manifestations of HD include mood and anxiety disorders as well as behavioral and personality changes. Psychosis...Read more

Int J Biol Macromol. 2026 Apr;357:151572. doi: 10.1016/j.ijbiomac.2026.151572. Epub 2026 Mar 24.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and psychiatric impairments, partly due to disruptions in neurotrophin signaling. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3) play critical roles in neuronal survival,...Read more

Biochem Biophys Res Commun. 2026 May 21;814:153639. doi: 10.1016/j.bbrc.2026.153639. Epub 2026 Mar 18.ABSTRACTHuntington's disease (HD) is a devastating neurodegenerative disorder caused by mutant huntingtin protein, leading to progressive motor, cognitive, and behavioral decline. This study investigates the dysregulation of sphingomyelin (SM) metabolism, the most abundant sphingolipid in cellular membranes, in...Read more